They showed that radioimmunotherapy induced changes in the tumor and immune microenvironment including transformation of epithelial cell subclusters from a malignant to a normal phenotype with some residual malignant cells, an increase in apolipoprotein E+ macrophages with high levels of M2 features, and a decrease in inhibition scores of residual exhausted CD8+ T and regulatory T cells. Here, CD8A is linked to neoplasm.