Looking for commonalities among all three infections, Cd40lg was the only gene significantly upregulated in all three compared to uninfected samples, while there were two genes significantly downregulated in all infected samples: Spp1 and Osm1. A few genes were significantly different in Pb Δpm4-Δbp2 and Pb Δlap, while also close to significant (p<0.15) in Py samples: Bmp7 (upregulated), Il1a and Cxcl12 (downregulated). The gene discussed is SPP1; the disease is infection.