We confirmed the presence of FTO-lncAML transcripts in RNA sequencing analyses from an additional dataset,14 and their association with high IRX3 expression (Figures 3C, 3D, and S3A) using Kallisto analysis20: all AML cases with high FTO-lncAML expression exhibited high IRX3 expression, whereas in the reverse analysis 50% of IRX3high AML samples expressed FTO-lncAML-transcripts. Here, IRX3 is linked to acute myeloid leukemia.