Recently, Arza-Apalategi and colleagues33 also noted the association of FTO-lncRNA expression (which they termed IFEX9) with the presence of a higher level of differentiation block in NPM1-mutated cases within the Beat AML cohort, although this was not linked functionally to either IRX3 or HOXA gene expression. This evidence concerns the gene IRX3 and acute myeloid leukemia.