Likewise, FTO-lncAMLhighIRX3high AML samples expressed lower levels of genes highly expressed in AML of myelomonocytic or monocytic/monoblastic (M4 or M5) subtypes by comparison with AML with minimal differentiation (M1), and vice versa for FTO-lncAML low IRX3high AML samples (Figure 7H). Here, FTO is linked to acute myeloid leukemia.