IRX3 and acute myeloid leukemia: Both FTO-lncAML and IRX3 KD led to markedly reduced clonogenic activity of Fujioka AML cells in semi-solid culture (Figures 5B and 5C), with upregulation of the monocyte/macrophage differentiation marker CD86 (Figures 5D and 5E), morphological features of differentiation in cytospin analyses (Figure 5F) and modest apoptosis in the case of the FTO-lncAML KD1 construct (Figure S6A).