Interestingly, evaluation of H3K27Ac patterns in normal CD34+ HSPCs—where FTO-lncAML is not expressed (Figure S4A)—revealed a pattern qualitatively similar to that seen in FTO-lncAMLlowIRX3low AML cases (Figures S3B and S4B).21 The gene discussed is CD34; the disease is acute myeloid leukemia.