Among the combined feature-type models [all features, parsimonious (10 and 20 feature), GLM, and Cox], LDH levels, Ki-67 proliferation index (%), blood counts (WBC, platelets, hemoglobin), B2M levels, bone marrow infiltration, and age at diagnosis were the most significant prognostic factors for MCL. The gene discussed is B2M; the disease is mantle cell lymphoma.