KCNA3 and myocardial ischemia: This might be attributed to nicorandil's dual action as a potassium channel opener and a nitrate-like drug, which not only dilates coronary vessels, improves myocardial blood flow, and relieves myocardial ischemia but also exhibits beneficial effects in suppressing inflammatory responses, improving cardiac function, and inhibiting platelet aggregation. Mitochondrial ATP-sensitive potassium channels play a dominant role in local myocardial ischemic preconditioning and cardiac protection.