MBP and idiopathic scoliosis: Plasma from patients who had no disease, or patients with CP, idiopathic scoliosis, and both CP plus scoliosis, were studied by ddPCR for MBP mRNA and by ELISA for MBP protein and downregulation of MBP was found in all cases, although downregulation of MBP was greatest in the patients with CP/scoliosis (Figure 1).