It is remarkable that in theearly stages of fibrosis, the α-SMA+ cells were not lumped together withthe FAP+ cells; before the onset of the fibrosis to cirrhosis transformation,α-SMA+ cells were noted in the sinusoids of the liver and necrosing focionly to be later localized both in the sinusoids and in the connective tissuesepta. Here, ACTA1 is linked to Cirrhosis.