For the purposes of this study, we had hypothesized that the increase in thelevel of mmp-9 mRNA might be associated with the rate ofconnective tissue formation in fibrogenesis; so, the objective of ourinvestigation was to probe for new data on the level of mmp-9mRNA expression and fibrogenic cell population at different stages oftoxic liver fibrosis. This evidence concerns the gene MMP9 and Hepatic fibrosis.