Theepithelial–mesenchymal transition (EMT) of tumor cells is one of thefirst steps in metastatic spread [43].Xu et al. [23] studied the role ofMALAT1 in EMT in breast cancer patients and found that MALAT1 promotesin vitro migration and invasion of breast cancer cells(MDA-MB-231, MDA-MB-453, MCF10A, SK-BR-3, and BT549); the lower MALAT1expression level is associated with metastatic breast cancer; i.e., MALAT1 actsas an EMT inducer by activating the PI3K-Akt pathway [23]. The gene discussed is AKT1; the disease is breast carcinoma.