Targetedinactivation of the MALAT1 gene in a breast cancer model intransgenic mice without altering the expression of neighboring genes was shownto promote lung metastasis, and this phenotype can be reversed by geneticinsertion of MALAT1. Identically, MALAT1knockout in human breast cancer cells confers metastatic ability,which is eliminated by MALAT1 re-expression [53]. The gene discussed is MALAT1; the disease is breast carcinoma.