Podocyte and Endothelial cell:In the pathological condition of high glucose, the abnormal renal expression of VEGF, angiopoietins, TGF- β, and endothelin-1 in early Diabetic nephropathy (DN) induces endothelial cell dysfunction and contributes to the disappearance of podocyte foot processes. This evidence concerns the gene EDN1 and liver dysplastic nodule.