Furthermore, in adjusted model III (adjusted sex, age, duration of diabetes, hypertension, HbA1c, total cholesterol, BMI, eGFR, direct bilirubin, PRP degree, and anti-VEGF therapy), the results revealed an inverse association between DME and WBC count, monocyte count, eosinophil count (OR = 0.75, 95% CI: 0.59, 0.95; p = 0.0153; OR= 0.07, 95% CI: 0.00, 0.92; p = 0.0431; OR= 0.03, 95% CI: 0.00, 0.88; p = 0.0420, respectively). This evidence concerns the gene VEGFA and diabetes mellitus.