This study shows that ER(-)/PR(+) breast cancer has higher rates of T3-4 stage, invasive non-special pathological type, and a high G3 ratio than ER(+)/PR(+) or ER(+)/PR(-) breast cancer, where there are significant differences, but these rates are not significantly different from those of ER(-)/PR(-) cancer. The gene discussed is ESR1; the disease is breast carcinoma.