ESR1 and breast cancer: The clinical features and prognosis of ER(-)/PR(+) breast cancer are similar to those of ER(-)/PR(-).The characteristics of a high T3-4 stage ratio, a high proportion of non-special invasive types, a high histological grade, and a high HER-2 positive rate indicate that this subtype represents a group of hormone receptor-positive tumors with high malignancy and poor prognosis.