GLA and Fabry disease: Among genetically determined diseases affecting the cardiovascular system, FD is a X-linked lysosomal storage disorder caused by pathogenic variants in the GLA gene that results in reduced α-galactosidase A (α-Gal A) enzyme activity and consequent accumulation of globotriasylceramide (Gb3) in a wide range of cells, including ECs (Ortiz et al., 2018).