In contrast, in the acetylcholine‐directly induced type which is also recognized as Cholinergic Urticaria with anhidrosis/hypohidrosis, eccrine sweat glands lack the expression of CHRM3 receptors thus the expression of CHRM3 is absent in anhidrotic areas and slightly present in hypohydrotic areas. This evidence concerns the gene CHRM3 and hypohidrosis.