NELFCD and infection: Whereas the infection of mice with an HK cda1Δcda2Δcda3Δ resulted in a controlled induction of pro-inflammatory response, which was accompanied by a Th-1 type adaptive protective response, infection with an HK chs3Δ resulted in an uncontrolled inflammatory response, resulting in early morbidity (Upadhya et al., 2016; Hole et al., 2020).