Many of these symptoms are initially mild, and can masquerade as common diseases of childhood.2 In children, the signs of type 1 diabetes result from the increase in glucose in the blood, triggering both osmotic removal of fluid from tissue and osmotic diuresis (which in turn increases thirst) and loss of insulin that is critical for entry of glucose into the cells of the body where it can be metabolized into energy (fatigue). Here, INS is linked to type 1 diabetes mellitus.