MMP9 and non-small cell lung carcinoma: The reduction effects of Rutin-loaded liquid crystalline nanoparticles (Rutin-LCNs) on NSCLC proliferation and migration were shown (Paudel et al., 2021), which is suggested to result from its inhibitory effect on the MMP-9 expression and prevent the degradation of the extracellular matrix (ECM) component.