Chlorin e6 loaded by iron oxide NPs linked with glucose significantly enhanced the uptake of Ce6 by lung cancer cells and produced more ROS, damaged the DNA of lung cancer cells, and thereby activated STING and upregulated the expression of IFN-β, HMGB1, and HSP90, indicating augmented immunogenicity of lung cancer cells (Yu et al., 2022). This evidence concerns the gene HMGB1 and lung carcinoma.