After the molecular identification of VRAC (Voss et al., 2014), his group has demonstrated that VRAC participates in a wide array of processes, including resistance to cancer drugs (Planells-Cases et al., 2015), secretion of insulin by pancreatic β-cells (Stuhlmann et al., 2018), enhancing innate immunity by transporting the messenger molecule cGAMP (Zhou C. et al., 2020) and proximal tubules function and integrity (López-Cayuqueo et al., 2022). Here, INS is linked to cancer.