Downregulation of LRRC8A subunit has been reported to suppress the growth or proliferation of different cancer cell types, including human glioblastoma cells (Rubino et al., 2018), colorectal carcinoma cells (Fujii et al., 2018), esophageal squamous cell carcinoma cells (Konishi et al., 2019), gastric cancer (Kurashima et al., 2021), colon cancer (Zhang et al., 2018; Zhang et al., 2023) and cervical cancer (Chen et al., 2023), while LRRC8A overexpression reportedly facilitated hepatocellular carcinoma cell growth (Lu et al., 2019). Here, LRRC8A is linked to hepatocellular carcinoma.