Some mutations have been involved in the risk stratification of AML, such as NPM1, RUNX1, c-KIT, RUNX1-RUNX1T1, CEBPA, PML-RARα, BCR-ABL1, ASXL1, TP53, FLT3-ITD, and MLL [11, 12]. The gene discussed is RARA; the disease is acute myeloid leukemia.