A four-CRL signature, with MAP4K3-DT, lnc-TCEA3-1, MIR9-3HG, and CDKN2A-DT, was finally constructed, and the risk score of HNSCC patients was expressed as follows: risk scores = (0.0079 × expMAP4K3-DT) + (−0.0108 × explnc-TCEA3-1) + (−0.1030 × expMIR9-3HG) + (−0.1181 × expCDKN2A-DT) (Figure 6A). This evidence concerns the gene TCEA3 and head and neck squamous cell carcinoma.