A total of 16 CRLs, which included MIR9-3HG, BACE1-AS, lnc-FGF3-4, LINC01767, APLC4, lnc-RPS25-5, lnc-TCEA3-1, lnc-COG5-3, MSC-AS1, MAP4K3-DT, lnc-SOS1-1, LMF1-AS1, lnc-ACTR8-1, lnc-YARS2-4, SNHG20, and GAS5-AS1 had significant effects on OS probability of HNSCC patients. Here, BACE1 is linked to head and neck squamous cell carcinoma.