Moreover, MIR9-3HG and CDKN2A-DT, the expression-correlated lncRNAs of CDKN2A, are upregulated in HNSCC and may be improve the resistance of HNSCC cells to copper-induced cell death through regulating expression of CDKN2A. Here, CDKN2A is linked to head and neck squamous cell carcinoma.