Moreover, either up-regulation or down-regulation of miRNAs also known as “onco-miRNAs” are involved in CRC progression and metastasis contributing to dysregulate several signaling pathways, including mitogen-activated protein kinases (e.g., miR-422a, miR-195), Wnt (e.g., miR-135a, miR-135b, miR-155, miR-17–5p, miR-224), transforming growth factor-β (e.g., miR-224, miR-20a-5p) and epithelial-to-mesenchymal transition (EMT) (e.g., miRNA-155, miR-34) (38–40). This evidence concerns the gene WNK2 and colorectal carcinoma.