Compared to SIRT1f/f mice, icSIRT1−/− showed significant downregulation of PGC‐1α and carnitine palmitoyltransferase 1β (CPT1β) under acute ischemia, while PGC‐1α, CPT1β, and CD36 were reduced upon I/R stress (Figure 6b). This evidence concerns the gene PPARGC1A and ischemia.