Given the centrality of TGF‐β1/Smad3 signalling in renal fibrosis, we subsequently checked the changes in Smad3 signalling and found that silencing EVL could reduce the phosphorylation and nuclear translocation of Smad3 without any significant effect on Smad3 levels, which implies that EVL may promote renal fibrosis by modulating TGF‐β1/Smad3 signalling. Here, SMAD3 is linked to renal fibrosis.