Based on the finding that METTL3 mediates m6A modification of EVL mRNA in renal fibrosis, promoting its stability, as well as the nonnegligible roles of IGF2BP1/2/3 in maintaining the mRNA stability where m6A modifications occur,26 we sought to explore whether these reader proteins impact the m6A modification of EVL. The gene discussed is METTL3; the disease is renal fibrosis.