After clarifying the importance of METTL3 in the mouse renal fibrosis models induced by UUO and I/R, we also assessed the function of METTL3 in TGF‐β1 (5 ng/mL)‐ and H/R (9/3 h, three cycles)‐induced fibrotic responses in HK‐2 cells. The gene discussed is TGFB1; the disease is renal fibrosis.