To evaluate the influence of METTL3‐dominated m6A modification on renal fibrosis, we performed relevant experimental studies using Ksp‐Cre‐METTL3 (Flox/Flox) conditional knockout (cKO) mice and small interfering RNA (siRNA)‐silenced renal tubular epithelial cells (HK‐2). The gene discussed is METTL3; the disease is renal fibrosis.