INS and obesity due to melanocortin 4 receptor deficiency: Mechanistic studies suggest that miR-374a-5p may be involved in the inflammatory response by affecting C–C motif ligand (CCL) 2, which further interferes with insulin metabolism in individuals with obesity [73]; visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were collected from patients in a study cohort comprising 28 individuals with BMI ≥ 30 kg/m2 and 30 individuals with BMI < 30 kg/m2) [72].