Interestingly, expression of TJP1, F11R, OCLN and CLDN5 were transiently increased after 2 or 4 days of infection before their downregulation (median increase up to 28.4% for TJP1, 33.5% for F11R, 110.4% for OCLN and 51.6% for CLDN5). The gene discussed is CLDN5; the disease is infection.