In recent years, several studies have shown that women with PCOS present with chronic low-grade inflammation, indicating abnormal expression of the proinflammatory cytokines interleukin-1 (IL-1), CRP, and interleukin-18 (IL-18), as well as endothelial dysfunction and increased oxidative stress [43–46]. This evidence concerns the gene IL18 and polycystic ovary syndrome.