In this study, we performed a comparison study of the phenotypes of single TAM gene deficient mice in the K/BxN serum transfer-induced arthritis (K/BxN-STIA) model and inveistigated the potential mechanism by which Tyro3, Axl, and Mertk have distinct or overlapping functions in RA. The gene discussed is MERTK; the disease is arthritic joint disease.