For example, the HPSE eRNA produced by heparanase can promote cancer progression by driving the chromatin loop and regulating the hnRNPU/p300/EGR1/HPSE axis [72]; Kallikrein 3e (KLK3e), an androgen-induced eRNA, can promote the spatial interaction between the androgen receptor (AR)-dependent gene KLK3 enhancer and KLK2 promoter, and enhance long-distance KLK2 transcription activation [92]. This evidence concerns the gene KLK2 and cancer.