CD4 and neoplasm: Using flow cytometric analysis, we also found that the numbers of CD11b+LY6C+LY6G-M-MDSCs, CD11b+LY6C-LY6G+G-MDSC and CD4+CD25+Foxp3+T-reg cells in the tumour microenvironment were remarkably reduced, indicating that naphplatin treatment may terminate the vicious TAMs-MDSC-Treg triangle [37], thus promoting the antitumor immunity.