To further explore the relationship between antitumour activity and immune cells, the blood, tumour and spleen tissues (Fig. S47d) in the above antitumor assays in vivo in Fig. S45 were collected and analyzed by flow cytometry, to determine macrophages, M1/M2-macrophages, CD45+, CD19+ B cells, CD5+ T cells, CD4+ T cells, CD8+ T cells, Treg, dendritic cells, mMDSCs, and gMDSCs. This evidence concerns the gene CD4 and neoplasm.