After treatment of CT-26 colorectal carcinoma cells with naphplatin (Fig. S48a-b), three ICD biomarkers were observed, including HMGB1 release from the nuclei to the cytoplasm, CRT exposure, and a higher extracellular ATP secretion (151.67 nM) than the intracellular level (139.34 nM), which had not been observed in the cisplatin group [36]. The gene discussed is HMGB1; the disease is colorectal carcinoma.