TGF-β is shown to increase the expression of EGFR by stimulating the expression and secretion of multiple ECM components, such as collagen I (COL1A1) and fibronectin (FN1) in stromal fibroblasts, and ECM cross-linking enzymes such as lysyl oxidase (LOX) in BC cells, enhancing the anoikis resistance effect of BC [108]. This evidence concerns the gene EGFR and breast cancer.