Briefly, onabotulinumtoxinA works for the prevention of migraine by decreasing the release of excitatory and proinflammatory neurotransmitters and neuropeptides, including calcitonin gene–related peptide (CGRP) and glutamate from primary sensory afferents as well as reducing insertion of TRPV1 into the membranes of nociceptive neurons [5]. This evidence concerns the gene CALCA and migraine disorder.