FOXC2-AS1 recruits RNA methyltransferase NSUN2 to FOXC2 mRNA, increasing its m5C level and repressing its degradation, indicating that FOXC2-AS1 exerts oncogenic roles in GC by regulating the stability of FOXC2 mRNA in an m5C-dependent manner. The gene discussed is FOXC2; the disease is gastric cancer.