Hierarchical clustering showed the top10 upregulated DERs (CST1, SYT12, HTR3A, MNX1-AS1, TMPRSS11E, ABCA12, KCNMB2-AS1, BBOX1-AS1, CLDN10-AS1, and FOXD3-AS1) and top10 downregulated DERs (LINC00968, CA4, FENDRR, ANKRD1, LINC00551, GPD1, FABP4, NAV2-AS2, ACADL, and ADAMTS8) and indicated that these DERs could successfully distinguish the tumor samples from normal samples (Fig. 2B). This evidence concerns the gene CST1 and neoplasm.