MUC5AC and neoplasm: It is estimated that just one member of the mucin family, MUC1, is aberrantly expressed in more than half of carcinomas diagnosed per year in the United States6, a frequency matched by prototypical oncogenes such as RAS and MYC. In addition, common carcinomas, such as breast, ovarian and intestinal cancers, have mucinous forms, wherein tumor cells present as individual colonies suspended in a matrix of secreted mucin and polysaccharides7.