Moreover, consistent with the observations from Apcmin+/− mice (Fig. 2a and Extended Data Fig. 2a), MR also decreased the circulating fractions of CD3+ and CD8+ T cells in above tumour-bearing Balb/c mice (Fig. 2e and Extended Data Fig. 3a), and substantially reduced the abundance of circulating CD45+ immune cells, including T cells in tumour-free regular Balb/c mice (Extended Data Fig. 3b). This evidence concerns the gene CD8A and neoplasm.