Interestingly, according to the GWAS catalog genetic variants in these genes and others included in TRScol (i.e. CTNNB1, COPA, CCDC71 and BLOC1S2) have been associated with psychiatric disorders (e.g. schizophrenia, externalizing behavior, smoking initiation, autism spectrum disorder, anorexia nervosa, depression and anxiety disorder), cognitive function (e.g. intelligence, educational attainment and mathematical ability) or ADHD comorbid somatic traits like obesity or extreme body mass index, suggesting a potential importance of these genes in the context of ADHD and its comorbid conditions. The gene discussed is CTNNB1; the disease is obesity due to melanocortin 4 receptor deficiency.