Moreover, as a model system for the more challenging eukaryotic FeS helicases, such as FancJ, DDX11 and RTEL1, which have all being implicated in G4 metabolism, the study of the interaction between DinG and G4s in the absence and presence of G4 ligands may provide a framework to better harness the potential of G4 stabilization in genome stability and cancer onset and development. This evidence concerns the gene RNF2 and cancer.