PTEN and neoplasm: There was no OS difference in the Xe1000 + En160 versus En160 arms in patients whose tumours had PTEN H-score >80 (17.8 vs 17.4 months; HR 1.07, 95% CI 0.52–2.20) or >130 (17.8 vs 17.4 months; HR 1.18, 95% CI 0.55–2.53).