Indeed, the SK channels modulators recovered the abnormal PC firing and subsequently restored the impaired motor activity in SCA1-82Q transgenic mice24, in murine models of EA225–27, in mutant CACNA1A mice28, in SCA3 transgenic mice29, in SCA2-58Q mice18, and even in the murine model of Huntington’s disease (HD) YAC12830. This evidence concerns the gene ATXN3 and Huntington disease.