On the other hand, lack of the modulatory receptor Acvr1b/Tgfbr2 promoted constant activity of TGF-β through Tgfbr1/Tgfbr2 or Acvr1b/Tgfbr147 during NAFLD and HCC. The gene discussed is TGFBR2; the disease is hepatocellular carcinoma.