EGFR and lung adenocarcinoma: Moreover, in lung adenocarcinoma (LUAD) cell lines with EGFR mutation from DepMap, CISH expression exhibited a negative correlation with the AUC and half the maximal inhibitory concentration (IC50) of Afatinib, suggesting that the tumor cells with higher expression of CISH were more sensitive to Afatinib (Fig. 4n, o).