In addition, we found that signaling through the mitochondrial antiviral-signaling protein (MAVS), a central hub for signal transduction initiated by cytosolic pattern recognition receptors (PRRs) RIG-I or MDA5, is required for efficient CHIKV clearance, with viral particles being detected up to 10 days post infection (dpi) in Mavs−/− mice. This evidence concerns the gene MAVS and infection.