Of note, cardiac tissue of an infected Mavs−/− mice that succumbed to CHIKV infection at 15 dpi (Supplementary Table 1), showed substantial tissue damage featured by patchy myocyte dystrophic calcification affecting single myocytes, and focal myocarditis composed by inflammatory infiltrates of CD11b+ and CD3+ cells, with no signs of fibrosis (Supplementary Fig. 7). Here, ITGAM is linked to myocarditis.