In agreement with the importance of β-Catenin in regulating PSG expression and the role of PSGs in promoting VCaP cell growth, we demonstrated that β-Catenin is also required for VCaP cell growth (Supplementary Fig. 9a, b), suggesting that β-Catenin could be a therapeutic target of TMPRSS2-ERG and p53 mutant-positive PCa. Here, TP53 is linked to posterior cortical atrophy.