On the contrary, we found that depletion of PSGs individually or together only slightly inhibited growth of ERG fusion- and p53 mutation-negative benign prostatic cell lines BPH1 and RWPE1 (Supplementary Fig. 8b–e), suggesting an essential role of increased expression of PSGs for growth of TMPRSS2-ERG/p53 mutant double positive PCa cells. Here, TMPRSS2 is linked to posterior cortical atrophy.