We further showed that ERG knockdown in VCaP cells also downregulated CTNNB1 mRNA and β-Catenin protein level, albeit not as effectively as mutant p53 depletion (Fig. 4g, h), supporting a predominant role of GOF mutant p53 in regulation of β-Catenin expression in PCa cells. This evidence concerns the gene CTNNB1 and posterior cortical atrophy.