Exogenous nucleotides did not promote the growth of the SPOP Q165P PDXO after the treatment of OP (Supplementary Fig. 10c), suggesting that the anti-cancer effect of LEF1/TCF OP is largely mediated through the inhibition of pyrimidine synthesis in TMPRSS2-ERG/GOF p53 mutant PCa. Here, TMPRSS2 is linked to posterior cortical atrophy.