Meta-analysis of TCGA data showed that TMPRSS2-ERG fusion co-occurred with TP53 inactivation (including heterozygous and homozygous deletions, gene mutations and other alterations) in primary/localized PCa patient samples23 (Fig. 1a, b and Supplementary 1a), suggesting that both lesions might be involved in prostate tumorigenesis. This evidence concerns the gene ERG and posterior cortical atrophy.