TMPRSS2 and prostate neoplasm: Through integration analysis of this set of genes and the ERG ChIP-seq data generated from TMPRSS2-ERG prostate tumors in a previously reported GEM model25, we identified 531 ERG target genes that were highly upregulated in prostate tumors from Pb-T2-ERG;Trp53pcR172H/- mice compared to other genotypic littermates (Fig. 2b, c and Supplementary Data 2).