ERG and prostate neoplasm: Gene clustering analysis of the RNA-seq data revealed that prostate tumors from Pb-T2-ERG;Trp53pc-/- mice and Pb-T2-ERG;Trp53pcR172H/- PIN lesions shared 370 commonly upregulated genes, but had 901 and 304 uniquely upregulated targets, respectively (Fig. 2a and Supplementary Fig. 3a, b and Supplementary Data 1).