Notably, negative correlations between GAB1 and Smurf1 or Smurf2 were observed (Fig. 7A, F, and G), confirming the downregulated expression of Smurf1 and Smurf2 in Shh-MB and supporting a tumor-suppressive role of Smurf1 and Smurf2 during Shh-MB progression. Here, SMURF2 is linked to neoplasm.