KEGG pathway showed Croci Stigma active compounds enriched in pathway in cancer, signaling by receptor tyrosine kinase, signaling by nuclear receptors, P53 signaling pathway, ErbB signaling pathway, NF-Kappa B signaling pathway, cell cycle, interleukin-10 signaling, and transcriptional regulation by RNUX2, which are also related to cancer progression (Fig. 2B). This evidence concerns the gene EGFR and cancer.