TREM2 and Alzheimer disease: To further illuminate how Bace1 deletion or BACE1 inhibition would affect microglial activation and plaque clearance of 5xFAD and APP KI mice, we performed immunoblot assays of microglial-enriched proteins TREM2, IBA-1, and CD68 in the cerebral cortex of each AD mouse model (Fig. 8).