APP and Alzheimer disease: We found that 5xFAD and APP KI mice exhibit increased epileptiform seizures on EEG, which is in line with previous studies of AD mouse models that show reduced seizure thresholds and spontaneous seizure phenotypes (Moechars et al., 1996; Lalonde et al., 2005; Palop et al., 2007; Westmark et al., 2008; Minkeviciene et al., 2009; Siwek et al., 2015; Reyes-Marin and Nuñez, 2017).