However, the number of microglia per neuritic plaque were significantly reduced in both AD mouse models, as shown in Figure 7G (6.01 ± 0.44 in Bace1fl/fl/5xFAD vs 3.84 ± 0.19 in AZD3293-treated Bace1fl/fl/5xFAD, p < 0.001; 6.56 ± 0.55 in APP KI vs 4.77 ± 0.22 in AZD3293-treated APP KI, p < 0.05, n =100 plaques/mouse in 6 mice each group). This evidence concerns the gene APP and Alzheimer disease.