We show that 5xFAD and APP KI mice both exhibit sleep–wake disturbances, in the form of increased wakefulness and decreased NREM and REM sleep, consistent with sleep architecture changes seen in AD patients (Loewenstein et al., 1982; Prinz et al., 1982; Bliwise et al., 1989; Petit et al., 2004). This evidence concerns the gene APP and Alzheimer disease.