It was previously demonstrated that HP1γ functions as a coactivator of GR after its recruitment through the histone lysine methyltransferases G9a and GLP (EHMT2 and EHMT1, respectively) in lung adenocarcinoma and B-cell acute lymphoblastic leukemia (Poulard et al, 2017, 2018, 2019). The gene discussed is NR3C1; the disease is lung adenocarcinoma.