Similar expression patterns of collagens and MMPs in response to BNC2 depletion was also seen in HS578T cells, another mesenchymal-like breast cancer cell line that expresses abundant BNC2, and also in mesHMLE cells, an immortalized epithelial breast cell line driven toward a mesenchymal phenotype by 3 wk of TGF-β exposure (Fig 4G). The gene discussed is BNC2; the disease is breast cancer.