In the present study, TCF‐1+ TILs were more frequently found in LUAD patients with a higher tumor grade (p < 0.001), advanced pathological stage (p = 0.045), and greater CD8 expression (p = 0.036), but not age, sex, smoking history, tumor location, CEA level, or VPI. The gene discussed is CEACAM5; the disease is neoplasm.