Moreover, TCF‐1 negativity (HR: 0.410; 95% CI: 0.173–0.971; p = 0.043), CD8 negativity (HR: 0.307; 95% CI: 0.096–0.982; p = 0.047), TIM‐3 expression positivity (HR: 1.765; 95% CI: 1.074–2.901; p = 0.025), LAG‐3 expression positivity (HR: 1.743; 95% CI, 1.037–2.931; p = 0.036), PD‐1 expression positivity (HR: 1.941; 95% CI: 1.170–3.220; p = 0.010), pathological stage (HR: 2.923; 95% CI: 1.669–5.118; p< 0.001), and tumor grade 3 (HR: 5.809; 95% CI: 1.007–33.521; p = 0.049) were independent prognostic factors for a worse OS. The gene discussed is CD8A; the disease is neoplasm.