In contrast, coexpression of LEF‐1 and TCF‐1 proteins in patients with nasopharyngeal carcinomas were positively correlated with lymph node metastasis (p = 0.001 and p = 0.020, respectively), advanced clinical stage (p < 0.003 and p = 0.027, respectively), and poor survival status (p < 0.001 and p = 0.004, respectively). This evidence concerns the gene LEF1 and metastatic malignant neoplasm in the lymph nodes.