The presence of disordered segments has also been verified in other proteins such as FUS (214) and TIA-1 (215), associated with ALS; PrP, associated with Creutzfeldt-Jakob syndrome (216, 217); Musashi-1,2, associated with AD (218, 219); and Huntingtin, associated with Huntington’s disease (220). The gene discussed is PRNP; the disease is Alzheimer disease.