CARM1 is required for ER-dependent cell cycle progression in BC cells both by promoting the expression of E2 promoter binding factor 1 (E2F1) transcription factor and acting as a coactivator for E2F1, thus regulating the expression of E2F1-target genes, such as the gene encoding the G1/S-specific cyclin E1 (87, 88). The gene discussed is E2F1; the disease is breast cancer.